Abstract

A reaction sequence involving ortho-lithiation of [15N]-(tert-Butoxy-carbonyl)aniline, quenching with Bu3SnCl, palladium catalyzed coupling with bromobenzene, and deprotection provides efficient access to [15N]-2-aminobiphenyl (4). Compound 4 is converted to [15N]-carbazole via diazotization, treatment with NaN3, and heating to promote intramolecular nitrene insertion.

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