An efficient synthesis and antimicrobial screening of new hybrid molecules containing coumarin and indenopyridine moiety

Abstract

A novel series of hitherto unknown 3-(4-aryl-5H-indeno[1,2-b]pyridin-2-yl)coumarin derivatives 3a–r have been synthesized by the reaction of 3-coumarinyl methyl pyridinium salts 1a-c with appropriate 2-arylidene-1-indanones 2a–f under Krohnke’s reaction condition so as to investigate their in vitro antimicrobial activity. Structures of the target compounds 3a–r were characterized by their spectral and elemental analyses. Among the series, compound 3l displayed an encouraging antibacterial activity profile as compared to the reference drug ampicillin against tested bacterial strains.