An efficient regioselective copper-catalyzed approach to the synthesis of 1,2,3-triazoles from N-tosylhydrazones and azides

Abstract

An efficient regioselective copper-catalyzed strategy for the synthesis of 1,2,3-triazoles from N-tosylhydrazones and azides has been reported. This transformation opened a new route to synthesize 1,2,3-triazoles which is a common structural motif in natural products and pharmaceuticals. The reactions were smoothly under the optimized conditions and provided the desired product in good yields.