An efficient preparation of porous polymeric microspheres by solvent evaporation in foam phase

Abstract

Abstract This paper reports an efficient method of preparing porous polymeric microspheres by solvent evaporation in foam phase, in which phase separation between polymer and porogen occurs in foam phase instead of that in water phase by using the traditional solvent evaporation method. The method provides outstanding features, including being time-saving, of high-yield and able for continuous production, in which formation of porous polymeric microspheres finished within 3 min with a high production yield up to approximate 95 wt% and the process was able to be developed into a continuous process for production of porous polymeric microspheres. It was also universal to non-crosslinked polymers since the method is a development on the traditional emulsion solvent evaporation method. The new method is efficient and can be used potentially on the industrial scale for continuous production of porous polymeric microspheres.