An Efficient One‐Pot Synthesis of Highly Substituted Pyridone Derivatives and Their Antimicrobial and Antifungal Activity

Abstract

A series of carboxamide and cyano functionalized pyridone derivatives 4a–q have been synthesized via one‐pot synthesis of various aldehydes 1a–q, acetoacetanilide 2, and cyanoacetamide 3. The reaction was simple and afforded pyridone derivatives in good yield, 89 to 93%. The novel pyridone derivatives were achieved by Hantzch one‐pot synthesis. Moreover, the synthesized compounds were screened against Gram‐positive and Gram‐negative bacteria and fungi for their activity. Among them, compound 4c shows highest inhibition at 4.25 mm against Staphylococcus aureus and 3.75 mm against Escherichia coli Gram‐positive and Gram‐negative bacteria, respectively.