Abstract
A novel and one-pot pseudo-four-component reaction between a series of arylglyoxals, malononitrile, 3-methyl-1-phenyl-1H-pyrazol-5-amine, and acetone in the presence of tetrapropylammonium bromide (TPAB) has been developed to synthesize a series of new substituted pyrazolo[3,4-b]pyridines, using water as an environmentally friendly solvent, in high to excellent yields.
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