An Efficient Microwave‐assisted Synthesis of Pyrido[2,3‐d]pyrimidine Derivatives

Abstract

AbstractA series of new pyrido[2,3‐d]pyrimidine derivatives were synthesized by multi‐component reactions of equimolar amount of aromatic aldehydes with barbituric acids (barbituric acid or 1,3‐dimethylbarbituric acid) and 5‐amino‐2‐methylbenzo[d]thiazol in mixed solvent of glacial acetic acid and ethylene glycol without catalyst under microwave irradiation. This one‐pot method has the advantage of good yields (90% –93%), simple workup procedure and short reaction time (5 min).