An Efficient, Microwave-Assisted, One-Pot Synthesis of Fluorinated 2,5-Disubstituted 1,3,4-Oxdiazole Derivative

Abstract

Efficient, rapid, and green procedure has been developed for the synthesis fluorinated 2,5-disubstituted 1,3,4-oxdiazoles using one-pot reaction of isoniazid or nicotic acid hydrazide and different fluorinated acid in the presence of ceric ammonium nitrate in PEG-400 as a solvent under microwave irradiation. The synthesized compounds were characterized by 1H NMR, 13C NMR, IR, and mass spectra. The yields are good to excellent, the process is rapid. The protocol was shown to have some advantageous such as short reaction time, low cost, eco-friendly catalyst, and mild reaction conditions.