Abstract
The first example of a one-pot tandem approach for the synthesis of 3,5-disubstituted-1,2,4-oxadiazole derivatives from benzyl halides and amidoxime is reported. Derivatives of 3,5-disubstituted 1,2,4-oxadiazole were obtained in excellent yields under mild conditions using DMSO in the absence of an additional oxidant. Benzyl bromides bearing a range of substituents proved to be suitable substrates for this method which provides a very efficient and convenient application of the Kornblum oxidation.
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