Abstract
An efficient enantioselective synthesis of florfenicol is accomplished in 44.7% overall yield from commercially available p-(methylsulfonyl)benzaldehyde. Key features of this synthesis are the asymmetric aziridination reaction mediated by the Wulff’s catalyst in situ derived from ( R)-VANOL and diastereoselectively ring-opening of (2 S,3 S)-fluoroaziridine 13.
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