An efficient copper-catalyzed N-arylation of pyridazinones with a structurally well-defined copper complex

Abstract

N-Arylation of pridazinone derivatives 1 with an aryl or heteroaryl bromide or iodide 2 has been achieved in 70–94% isolated yield using catalytic amounts of the stable and structurally well defined copper catalyst 4b under standard Ullmann–Goldberg reaction conditions. The structure of copper catalyst 4b was characterized by ESI-MS, DSC and the single crystal X-ray.