An efficient asymmetric aldol reaction of Chan's diene promoted by chiral Ti(IV)–BINOL complex

Abstract

1,3-Bis-(trimethylsilyloxy)-1-methoxy-buta-1,3-diene (Chan's diene) can be conveniently used in asymmetric aldol reaction with aromatic, heteroaromatic, α,β-unsaturated and aliphatic aldehydes in the presence of catalytic amounts (2–8% mol) of chiral Ti(IV)/( R)-BINOL complex.