Abstract
An efficient and direct protocol is described for the preparation of α-amino phosphonates derivatives by employing a multi-component, one-pot condensation reaction of aldehyde, amine and trialkyl phosphite in the presence of silica-supported perchloric acid (3mol%) under solvent-free conditions. The thermal solvent-free green procedure offers advantages such as shorter reaction time, simple work-up, high yield, recovery and reusability of catalyst.
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