An efficient and robust parallel scheduler for bioinformatics applications in a public cloud: A bigdata approach

Abstract

<p>In bioinformatics, genomic sequence alignment is a simple method for handling and analysing data, and it is one of the most important applications in determining the structure and function of protein sequences and nucleic acids. The basic local alignment search tool (BLAST) algorithm, which is one of the most frequently used local sequence alignment algorithms, is covered in detail here. Currently, the NCBI's BLAST algorithm (standalone) is unable to handle biological data in the terabytes. To address this problem, a variety of schedulers have been proposed. Existing sequencing approaches are based on the Hadoop MapReduce (MR) framework, which enables a diverse set of applications and employs a serial execution strategy that takes a long time and consumes a lot of computing resources. The author, improves the BLAST algorithm based on the BLAST-BSPMR algorithm to achieve the BLAST algorithm. To address the issue with Hadoop's MapReduce framework, a customised MapReduce framework is developed on the Azure cloud platform. The experiment findings indicate that the suggested bulk synchronous parallel MapReduce-basic local alignment search tool (BSPMR-BLAST) algorithm matches bioinformatics genomic sequences more quickly than the existing Hadoop-BLAST method, and that the proposed customised scheduler is extremely stable and scalable.</p>