Abstract
An efficient and recyclable L-proline triflate ionic liquid catalyst for one-pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones via the multi-component Biginelli reaction
Highlights
A simple, efficient, and environmentally-friendly process has been developed for the synthesis of L-proline triflate ionic liquid (L-ProTfO) from L-proline and triflic acid using ultrasound irradiation
A large number of papers have previously reported the application of microwave irradiation (MW) and ultrasound irradiation in the synthesis of heterocyclic compounds. 27-33
An synthesizable and cost-effective L-proline triflate ionic liquid was prepared from L-proline and triflic acid using ultrasonic irradiation technology
Summary
A simple, efficient, and environmentally-friendly process has been developed for the synthesis of L-proline triflate ionic liquid (L-ProTfO) from L-proline and triflic acid using ultrasound irradiation. The Biginelli reaction was carried out using both conventional heating methods and microwave energy for comparison. An efficient pathway for the synthesis of L-ProTfO, an α-amino acid-based IL from Lproline (1) and triflic acid (2), has been developed under ultrasonic irradiation (Scheme 1).34 For the first time, L-ProTfO has been used as an efficient and green catalyst for the Biginelli reaction under solvent-free conditions. Synthesis of L-proline triflate using ultrasonic irradiation.
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