An Efficient and Novel Synthesis of Pregabalin with Enantioselective Enzymatic Hydrolysis using CAL-B Enzyme

Abstract

The present paper describes the CAL-B (Enzymatic) Isobutylpentanedioate was performed to prepare optically active (S)-3-(2-methoxy2-oxoethyl)-5-methylhexanoic acid. Based on this reaction, the synthesis of (S)-(+)-3-aminomethyl-5-methylhexanoic acid (S-Pregabalin) was achieved with a 70–75% overall yield.