An efficient and high yielding protocol for the synthesis of substituted dihydropyrimidin‐2(1h)‐ones and spiro‐fused heterocycles by involving tandem reactions

Abstract

Abstractmagnified imageA simple and efficient method has been developed for the synthesis of 3,4‐dihydropyrimidin‐2(1H)‐ones by a one‐pot three component cyclocondensation reaction of alkyl acetoacetates, aldehyde, and urea in the presence of a catalytic amount of the reusable catalyst zinc per chlorate hexahydrate, Zn(ClO4)2.6H2O (10 mol %) the scope of this protocol is utilized for the synthesis of mitotic Kinesin EG5 inhibitor monastrol and new class of fused heterobicyclic compounds in high yields.