Abstract
An efficient and facile synthesis of polydentate ligand pyridylpyrimidine-2-amine via a one-pot reaction of different aromatic aldehydes, 2-acetylpyridine and guanidine carbonate, in the presence of NaOH under solvent-free conditions, is reported. These compounds have four N-donors and they are classic polydentate ligands of many metal ions. Due to employing a one-pot, multicomponent reaction, this method offers several advantages including easy experimental work-up procedure, and lower cost, short reaction time, and especially high yields of products. This paper therefore develops a practical and convenient process for the synthesis of these ligands.
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