Abstract

An efficient and environment-friendly method for the synthesis of 3-haloimidazopyridine derivatives has developed by the halogenation of imidazoheterocycles with Bu4NX (X = Cl, Br, and I) using iodobenzene diacetate as oxidant in ethanol. This protocol features with short reaction time for bromination and iodination, ambient temperature, facile operation, good functional group tolerance and good yeilds.

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