Abstract
A Biginelli one-pot three-component reaction involving cyclohexanone, aromatic/or heterocyclic aldehyde, and urea thiourea or guanidine HCl was applied in this work to prepare quinazolin-2(1H)one derivatives under solvent free and microwave irradiation assistance as well as conventional method. The major advantages of this protocol are high yields, operational simplicity, short reaction time and environment friendly. The purity of the synthesized compounds was characterized by means of IR, 1 H NMR, 13 C NMR, mass spectral and elemental analysis.
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