Abstract
Bone repair devices with proper mechanical strength and high biocompatibilities are highly appealing in clinical treatment. The currently widely used Poly (ether ketone) (PEEK) substrate suffers poor hydrophilicity and thus risks potential failures. This study reports an effective surface engineering strategy to achieve biomimetic interfaces to enhance the biocompatibility and osteogenesis abilities of PEEK. The interface comprising collagen and CaP simulates nature bone tissues in both componential and porous structural traits. In vitro evaluations indicated that gene and protein expression towards osteogenesis on the modified PEEK surface effectively increased thanks to the special surface morphologies. In vivo experiments demonstrated that the modified PEEK substrates lead to remarkably stronger osteogenesis effects.
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