Abstract
The synthesis of side-chain 13C-labeled geranylgeranyl-4-hydroxybenzoic acids and geranylgeranyl-3,4-dihydroxybenzoic acids is described. The synthesis starts from O-protected methyl hydroxyiodobenzoates, which are transformed into Grignard reagents by low-temperature iodine-magnesium exchange according to Knochel’s procedure. Copper catalyzed cross-coupling with labeled geranylgeranyl bromide followed by deprotection affords the products with good yields and full retention of stereochemistry.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Paper version not known
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
