An effective LDs-targeted ratiometric fluorescent probe for sulfur dioxide derivatives

Abstract

In this work, a novel FRET-based fluorescent probe (named CBC) was developed to detect bisulfite with outstanding selectivity by ratiometric method. Probe CBC exhibited excellent sensitivity toward HSO3− within 1 equivalent. The cell imaging of CBC indicated that it could detect exogenous and endogenous bisulfite with excellent photostability and low cytotoxicity. What's more, probe CBC realized the lipid droplet targeting. Therefore, probe CBC has the capacity to be used as a biological tool to monitor the bisulfite changes in vivo.