Abstract
We have developed a ratiometric fluorescent probe based on ICT mechanism for imaging intracellular sulfite (SO32−) in HeLa cells. The probe could selectively stain cells with scarce cytotoxicity and excellent photostability. The probe displayed a high selectivity for sulfite over other anions and active small biological molecules including cysteine (Cys), homocysteine (Hcy) and glutathione (GSH) at room temperature. The reaction could complete within 30s and detection limit was as low as 76nM, which is superior to some reported probes. The detecting mechanism was proved by MS, 1H NMR and theoretical calculation. The probe can also detect endogenous sulfite in HepG2 cells.
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