Abstract

Fining effective and informative biomarker genes form microarray is very challenging. In order to develop an hybrid gene selection algorithm, numerous filter feature selection algorithms have been previously reported. This research paper aims to identify the filter method that will improve the performance of our previously proposed FF-SVM algorithm to find the minimum number of accurate genes that achieves high accuracy performance. Therefore, an experiment was conducted using four different filter methods: Maximum Relevance Minimum Redundancy (mRMR), Joint Mutual Information (JMI), F-score, and Double Input Symmetrical Relevance (DISR). This experiment was undertaken in two phases: the first phase was filter to SVM , to identify the minimum number of features (genes) which served to maximize the SVM classifier; the second phase was filter to FF-SVM , to ascertain the best suite filter method to our previously proposed FF-SVM algorithm. The result of this experiment would be the most suited filter method to the FF-SVM. In conclusion, we found that the f-score method outperformed other filter methods when combined with FF-SVM.

Highlights

  • Microarray data analysis provides valuable results towards the solution of gene expression profile problems

  • Our results showed that the f-score method outperforms the others filter methods, when combined with FFSVM

  • Our aim was to find a filter method that will improve the performance of our proposed FFSVM algorithm, by reducing data dimensionality and lower the search space complexity

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Summary

INTRODUCTION

Microarray data analysis provides valuable results towards the solution of gene expression profile problems. The typical features (genes) are ranked in a specific criteria and only the features with the highest scores are selected These features are used as an input for wrapper methods. In order to find the filter method that will improve the performance of our previously proposed FFSVM algorithm, we did an experiment using four different filter methods: Maximum Relevance Minimum Redundancy (mRMR), Joint Mutual Information (JMI), f-score, and Double Input Symmetrical Relevance (DISR). This experiment was done in two phases. Our results showed that the f-score method outperforms the others filter methods, when combined with FFSVM

FF-SVM ALGORITHM
FILTER METHODS
EXPERIMENT SETUP AND RESULT
Experimental Setup
MICROARRY DATASETS
FILTER TO CLASSIFIER RESULT
The Best Filter
Result comparision
Findings
CONCLUSTION
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