Abstract
BackgroundStroke survivors encounter emotional problems in the chronic phase after stroke. Post-stroke depressive symptoms have major impact on health-related quality of life (HRQol) and lead to increased hospitalization and therefore substantial healthcare costs. We present a cost-effectiveness and cost-utility evaluation of a cognitive behavioural therapy augmented with occupational and movement therapy to support patients with a stroke with depressive symptoms in goal-setting and goal attainment (augmented CBT) in comparison with a computerized cognitive training program (CogniPlus) as a control intervention.MethodsA trial-based economic evaluation was conducted from a societal perspective with a time horizon of 12 months. Stroke patients (aged 18+ years) with signs of depression (Hospital Anxiety and Depression Scale (HADS) – subscale depression > 7) were eligible to participate. Primary outcomes were the HADS and Quality Adjusted Life Years (QALYs) based on the three-level five-dimensional EuroQol (EQ-5D-3 L). Missing data were handled through mean imputation (costs) and multiple imputation (HADS and EuroQol), and costs were bootstrapped. Sensitivity analyses were performed to test robustness of baseline assumptions.ResultsSixty-one patients were included. The average total societal costs were not significantly different between the control group (€9,998.3) and the augmented CBT group (€8,063.7), with a 95 % confidence interval (−5,284, 1,796). The augmented CBT intervention was less costly and less effective from a societal perspective on the HADS, and less costly and slightly more effective in QALYs, in comparison with the control treatment. The cost-effectiveness and cost-utility analyses provided greater effects and fewer costs for the augmented CBT group, and fewer effects and costs for the HADS. Based on a willingness to pay (WTP) level of €40,000 per QALY, the augmented CBT intervention had a 76 % chance of being cost-effective. Sensitivity analyses showed robustness of results.ConclusionThe stroke-specific augmented CBT intervention did not show convincing cost-effectiveness results. In addition to other literature, this study provided new insights into the potential cost-effectiveness of an adjusted cognitive behavioural therapy intervention. However, as our study showed a 76 % chance of being cost-effective for one outcome measure (QALY) and did not provide convincing cost-effectiveness results on the HADS we recommend further research in a larger population.
Highlights
Stroke survivors encounter emotional problems in the chronic phase after stroke
The current study describes the cost-effectiveness and cost-utility of a cognitive behavioural therapy augmented with occupational and movement therapy to support stroke patients with depressive symptoms in goal setting and goal attainment for stroke patients suffering from post-stroke depressive symptoms, in comparison with a computerized cognitive training program (CogniPlus) as a control intervention
Design The current study describes an economic evaluation which was linked to the Restore4stroke cognitive behavioural therapy (CBT) study: a multi-centre randomized controlled trial (RCT) conducted in five rehabilitation centres and in the rehabilitation department of one general hospital in the Netherlands
Summary
Post-stroke depressive symptoms have major impact on health-related quality of life (HRQol) and lead to increased hospitalization and substantial healthcare costs. Recent data from the National Stroke Association (United Kingdom) show that approximately one-third of stroke survivors is affected by varying degrees of post-stroke depression amongst other symptoms [10]. These symptoms often coincide with increased feelings of anxiety [11]. Besides the major impact on health-related quality of life (HRQol) [12], post-stroke depressive symptoms are associated with increased hospitalization and substantial healthcare costs [13]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
