Abstract
A series of novel spiro derivatives containing pyrido[1,2-a]pyrimidine and quinoline moieties was designed and synthesized, and their structures were characterized by 1H, 13C NMR, IR, Mass Spectral and elemental analysis. This protocol has the advantages of good yields, broad substrate scope and simple work-up. Their antimicrobial activity against a panel of various bacterial strains and unicellular and multicellular pathogenic fungal strains were evaluated, and the result indicated that some of the title compounds showed excellent activities against reference drugs. The spiro compounds with different substituents, namely 6 a, 6 c and 7 e displayed promising in vitro antimicrobial activity.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
