Abstract
An efficient and accessible procedure for the synthesis of 1,3,4-oxadiazines was developed. Reaction involves the cyclocondensation of phenylhydrazones catalyzed by a mild base triethylamine to produce 1,3,4-oxadiazines in good yields. The synthesized new compounds were characterized by spectral studies and elemental analyses and were screened to explore in vitro antimicrobial activity against bacteria and fungi species. The compounds displayed good to excellent potency against tested microorganisms, in particular, compound with chloro substitution showed good antimicrobial potential.
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