An easily accessible internal charge transfer chemosensor exhibiting dual colorimetric and luminescence switch on responses for targeting Cu 2+

Abstract

A new internal charge transfer probe, MIZON was synthesized by condensing Michler's ketone with 4-( N, N′-dimethylamino)benzhydrazide. The spectrophotometric and fluorimetric titrations with metal ions of biological and environmental importance were performed in H 2O–CH 3CN (1:1 v/v) system buffered by Tris–HCl, pH = 7.4 ± 0.1. The probe, MIZON was found to interact selectively with Cu 2+, inducing remarkably high absorbance red shift by 240 nm and 11-fold enhancement in the emission intensity. In contrast, several other metal ions, viz. Li +, Na +, K +, Ca 2+, Mg 2+, Ba 2+, Pb 2+, Co 2+, Cd 2+, Zn 2+, Ni 2+ and Hg 2+, even at substantially higher concentration than Cu 2+, did not exert significant perturbation in the photophysical profile of the probe. The detection limit of Cu 2+, calculated from the more sensitive fluorescence data was found to be 5.5 × 10 −7 M. Potential, therefore is clearly available in MIZON to detect Cu 2+ in micromolar range via dual visible color change from yellow to green and fluorescence switch-on response.