Abstract
This case is presented because it demonstrates the possibility of the untoward action of dinitrophenol on the otologic apparatus in the treatment of obesity. A. M., a white woman, aged 28, who weighed 150 pounds (68 Kg.), was given dinitrophenol for weight reduction in June 1933. The dose consisted of a 5 grain (0.3 Gm.) capsule of alpha-dinitrophenol administered orally once a day. Immediately following the first capsule a burning sensation at the back of the throat was experienced, which lasted ten minutes. During the next few hours profuse perspiration, a dull headache and general bodily weakness occurred. At the end of four days, after 20 grains (1.3 Gm.) of the drug had been taken, the symptoms increased. There was severe exhaustion, accompanied by a rash over the chest and extreme dizziness and a sensation of fulness and pain in both ears. The dinitrophenol was then discontinued, the rash cleared
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