AN AYURVEDIC POLYHERBAL FORMULATION PDBT FOR DYSLIPIDEMIA AND PREVENTION OF CORONARY ARTERY DISEASE (CAD) IN PRE-DIABETIC INDIVIDUALS

Abstract

Pre - diabetes is a ‘ gre y area ’ between normal and diabete s. Various studies have shown that pre - diabetic subjects who developed diabetes had higher triglyceride and cholesterol values at baseline. At the time of diagnosis of diabetes around half of the patients will show s ome evidence of coronary artery disease. Treating dyslipidaemia in pre diabetes condition can not only reduce the conversion rate to diabetes but also occurrence of coronary artery disease ( CAD) . The Purpose of present study was to see whether an Ayurvedic polyherbal formulation PDBT which conta ins water extracts of Guduchi ( Tinospora cordifolia ) , Vijaysar ( Pterocarpus marsupium ), Gudmar ( Gymnemma sylvestre ) , Karvellak ( Momordica charantia ) and Shunthi ( Zinziber officinale ) can reduce mild to moderate dyslipidaemia in Pre - diabetic state as compar ed to placebo. A double blind placebo controlled (Randomized Controlled Trial) RCT was conduc ted on 100 patients ( 50 in each group) having m ean age 48.78 ± 10.098 ; for 6 months to see the effect of polyherbal formulation as compared to placebo in pre - di a be tic individuals. A diagnostic criterion for pre - diabetes was set according American Diabetic Association (ADA) 2000. Cholesterol , High Density Lipoprotein ( HDL ) , was done with Wyebenga and Pileggi ’s method / Bio - lab Kit. Triglycerides were estimated by enz ymatic Kit method. Blood sugar level (BSL) was calculated by Glucose oxidase - peroxidase ( GOD - POD ) method. Low Density lipoprotein (LDL), Very Low Density Lipoprotein (VLDL) was calculated by formula. These investig ations were done before treatment (BT) an d after treatment (AT) . Unpaired T and paired T test were applied by INSTAT 2 software as a test of significance. Mean Cholesterol before treatment and after treatment 200.04 ± 41.6 and 172.09 ± 42.29, Mean HDL before treatment and after treatment 44.544 ± 10.517 and 47.30 ± 8.35, Mean LDL 116.37 and 92.91. Triglycerides before treatment and A. T. 160.16 ± 132.02 in PDBT treated group. W hile in placebo treated group these val ues were increased from 170.53 ± 32.05 to 191.62 ± 36.75 , for Cholesterol before tr eatment and after treatment . LDL increased from 92.85 ± 31.19 to 99.139 for LDL. While for triglycerides values increased from 165.75 ± 44.33 to 211.18 ± 46.7.