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Abstract
Introduction:- Sickle cell anemia is a term for a group of genetic diseases characterized by the production of hemoglobin (Hb) "S". This is the result of replacing the base pair thymine at the 6th position of the β-globin gene on chromosome 11 with adenine and replacing valine with glutamic acid. A single amino acid substitution is the reason for the profound changes in the stability and solubility of the hemoglobin "S" molecule. Due to its chronic nature and painful crisis, children’s quality of life is difficult. From now on, there is no final treatment other than a successful bone marrow transplant. Its symptoms and the nature of the disease can be compared with Pandu. If a drug improves the quality of life and maintains the health of the patient, then the drug and efforts will be beneficial to society. Material and Methods:- A 9-year-old male patient was diagnosed with sickle cell anemia. Symptoms include joint and limb pain, anorexia, fatigue, loss of appetite, and weight loss. approached the OPD, department of Kaumarbhritya, Parul Institute of Ayurved, Vadodara. Observations and Results:-The patient is taking modern medicine (1 mg folic acid once a day). The Childs parents also wanted to take Ayurvedic medicine, so they came here for 2 months of Ayurvedic medicine treatment, during which he did not have a pain crisis.Weight improved From 16 kg to 18 kg.The quality of life of a patient is also improved. Conclusion:-Therefore, the purpose of this case study is to study the pathophysiology and treatment of sickle cell anemia from an Ayurvedic perspective and to study the possible mechanism of action of the drug.
Highlights
Sickle cell anemia is an autosomal recessive genetic disease of red blood cells. It is called a "molecular" disease because it is the result of amino acid mutations in the hemoglobin molecule(1)
This is the result of replacing adenine with base pair 6 of the βglobin gene on chromosome 11 and replacing valine with glutamate
Bantu haplotype is common in Africa, Mediterranean countries, North and South American countries.The term SCD encompasses several different genotypes; the most common are homozygous sickle cell anemia (SS), heterozygous (AS), and sickle thalassemia (Sβ0), and the less common forms are SD, Punjab disease, SO Arab disease(3)
Summary
Sickle cell anemia is an autosomal recessive genetic disease of red blood cells It is called a "molecular" disease because it is the result of amino acid mutations in the hemoglobin molecule(1). Bantu haplotype is common in Africa, Mediterranean countries, North and South American countries.The term SCD encompasses several different genotypes; the most common are homozygous sickle cell anemia (SS), heterozygous (AS), and sickle thalassemia (Sβ0), and the less common forms are SD, Punjab disease, SO Arab disease(3). Total duration- 60 days. Drug- Dadimadi avaleha Dose – 25 gm BD Before food , Anupana- luke warm water
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