Abstract
In 2017, outbreaks of low and highly pathogenic avian H7N9 viruses were reported in four States in the United States. In total, over 270 000 birds died or were culled, causing significant economic loss. The potential for avian‐to‐swine transmission of the U.S. avian H7N9 was unknown. In an experimental challenge in swine using a representative low pathogenic H7N9 (A/chicken/Tennessee/17‐007431‐3/2017; LPAI TN/17) isolated from these events, no infectious virus in the upper and minimal virus in the lower respiratory tract was detected, nor was lung pathology or evidence of transmission in pigs observed, indicating that the virus cannot efficiently infect swine.
Highlights
In March 2017, highly pathogenic avian influenza (HPAI) and low pathogenic avian influenza (LPAI) A(H7N9) of North American lineage, distinct from the Asian lineage, were reported in poultry farms in Tennessee, USA.[1]
Experimental challenge of pigs with a LPAI H7N9 isolate resulted in minimal replication in the lung with no evidence of transmission to contact pigs, suggesting a low risk to the swine population
Due to logistical challenges of studying the HPAI H7N9, we tested the LPAI H7N9 TN/17 isolate due to its genetic relatedness to the HPAI that was detected at the same time
Summary
In March 2017, highly pathogenic avian influenza (HPAI) and low pathogenic avian influenza (LPAI) A(H7N9) of North American lineage, distinct from the Asian lineage, were reported in poultry farms in Tennessee, USA.[1]. Avian-origin genes have emerged and had sustained circulation among influenza A viruses (IAV) in swine.[5,6,7] To assess the risk of this novel reassortant virus spilling over into the swine population, we experimentally challenged naïve and pre-immune pigs with LPAI TN/17 to examine pathogenesis and transmission
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
