Abstract
Autophagy is an important self-degradative mechanism that plays a key role in treating neurodegeneration diseases. This research aimed at discovering bioactive compounds from Aster koraiensis. A new triterpene saponin, astersaponin I (1), was isolated from the EtOH extract of A. koraiensis. The structure of 1 was characterized by spectroscopic methods, ECD calculation, and acid hydrolysis. The biochemical analysis showed that compound 1 significantly increased the expression of microtubule-associated protein 1A/1B light chain 3B (LC3-II) expression in SH-SY5Y cells, which indicates the induction of autophagy. Thus, further study may be needed to clarify whether compound 1 exerts beneficial effects on neurodegeneration diseases like Parkinson’s disease through autophagy induction.
Highlights
Aster koraiensis Nakai (Korean starwort), belonging to the family Asteraceae, is a perennial herb originating in Korea and mainly distributed in temperate regions of the Korean peninsula and JejuIsland
Previous phytochemical studies demonstrated that it contains polyacetylene [2,3], benzofuran [4], and sesquiterpenoids [5], which are associated with several biological activities, such as cytotoxicity and immune diseases [2,3]
Autophagy regulates the balance of energy sources and offers an adaption for nutrient stress, it promotes the degradation of damaged cytosolic components or organelles before they become toxic to cells [6,7,8]
Summary
Aster koraiensis Nakai (Korean starwort), belonging to the family Asteraceae, is a perennial herb originating in Korea and mainly distributed in temperate regions of the Korean peninsula and Jeju. Autophagy is very important for the treatment of various diseases, including neurodegeneration diseases [9]. Microtubule-associated protein light chain 3 (LC3) is conjugated to phosphatidylethanolamine to form LC3-II, which can be found on the membranes of autophagosomes. In search to todiscover discoverananautophagy-inducing autophagy-inducing molecule, confirmed by using western analysis that the. A bioassay-guided fractionation indicated that the n-BuOH fraction EtOAc showed a relatively weak autophagy inducing effect. This led to the isolation and structural characterization of of aa biologically biologically active active compound
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