Abstract
Introduction: Abnormal cortisol levels due to hypothalamic, pituitary or adrenal malfunction, such as in Cushing's syndrome and Addison's disease, can lead to severe metabolic imbalance. Current guidelines for the diagnosis of hypercortisolism recommend the measurement of cortisol in blood following stimulation or suppression tests, but also the measurement of integrated 24 hours cortisol secretion in urine or late night salivary cortisol. More recently, measurement of cortisol has also been proposed as a marker of selectivity of cannulation of the adrenal veins during adrenal vein sampling procedures. The latter, however, requires the availability of a very rapid cortisol measurement procedure.
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