Abstract
It was shown in vitro-on isolated mitochondria as well as on mitochondria from Ehrlich Ascites Tumor Cells-that adding of 2,4-dinitrophe- nol /DNP/ to the incubation medium leads to characteristic structural changes coinciding with adequate respiratory states. The aim of this study is to investigate, at the ultrastructural level, to what extent it would be possible to modify the configurational states in vivo on the model of the choroid plexus of rats' brain lateral ventricles. It produces the cerebrospinal fluid /CSP/, and is responsible for its composition through the active secretion of certain ions. ATP is indispensable in the process. It has been proved that DNP penetrates the plexus' epithelium and probably inhibits the active processes there by means of uncoupling the oxidative phosphorylation in the mitochondria.Material and MethodsWistar rats, weighed 280-330 g,were anesthetized with Nembutal /30 mg/kg i.p./ and fortal /1 mg/kg i.m./, then placed in stereotactic apparatus for ventriculo-cisternal perfusion.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings, annual meeting, Electron Microscopy Society of America
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
