An attempt to detect cell surface antigens in cultured human brain tumors by mixed hemadsorption test. First report.

Abstract

The mixed hemadsorption test using rabbit anti-human glioma serum was applied to investigate cell surface antigens of nervous tissue tumors, non-nervous tissue tumors, epithelial and mesenchymal cells. Gliomas, neurinomas, and fetal brain cells exhibited a strongly positive reaction. Meningiomas, a metastatic brain tumor originated from the lung and HeLa cells exhibited a moderately positive reaction. No positive reaction was detected in human skin or dural fibroblasts, or in kidney cells even at a high concentration of rabbit anti-human glioma serum.