Abstract
AbstractAn asymmetric synthesis of ((3R,6R)‐6‐methylpiperidin‐3‐yl)methanol 2, a potent dual orexin receptor antagonist MK‐6096 1 piperidine core unit, is described. The synthesis utilizes commercial available (S)‐propylene oxide as a starting material and organocatalyzed asymmetric Michael addition reaction as key step.
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