Abstract
We have developed a general, two-step protocol for the synthesis of chiral non-racemic coumarin anticoagulants (e.g. warfarin, coumachlor and acenocoumarol). This approach features a one-pot three-component tandem Knoevenagel–hetero-Diels–Alder reaction between in situ generated 3-arylidene-2,4-chromanediones and iso-propenyl ether derived from (−)-menthol.
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