An association study of histological types of gastric carcinoma with Helicobacter pylori infection.

Abstract

The aim of this study was to study the relation between histopathological classification of gastric carcinoma and Helicobacter pylori (H. pylori) infection. 200 patients with confirmed gastric carcinoma between January 2010 and January 2012 from our hospital were included. All these patients went through endoscopy and histological examinations for gastric carcinoma and immunological test for H. pylori infection. Patients were grouped according to the histological classification, and the infection rates of H. pylori in different groups were compared. Types of gastric cancer that was closely related to H. pylori infection were identified. Infection rate in patients with the intestinal type of gastric cancer was significantly higher compared to those with the diffuse type. For tubular type of carcinoma, the well to medium-differentiated group had a significantly higher infection rate than the poorly differentiated group. Helicobacter pylori infection and histological types were relevant. The effect of H. pylori infection on the intestinal type was more significant than that on the diffuse type. The infection rate of well-differentiated group was higher than that of the poorly differentiated group, which suggested an association between H. pylori infection and the degree of differentiation of tubular cancerous tissue.