An Association of Vitamin D Insufficiency with Elevated Serum Uric Acid Levels Among Postmenopausal Women

Abstract

Introduction: Deficiency of vitamin D and raised levels of serum uric acid are considered independent risk factors for causing cardiovascular diseases. Aims & Objectives: This study was carried out to study Serum Uric acid and Vitamin D levels in postmeopausal women to find association of hypovitaminosis D with hyperuricemia. Place and duration of study: It was a cross-sectional analytical study. Postmenopausal women more than 55 years of age with BMI between 25-30 kg/m2 were included in the study. The study was conducted at the Department of Biochemistry and Chemical Pathology, Shaikh Zayed Federal Postgraduate Medical Institute, Lahore over a period of six months. Material & Methods: Eighty subjects were included in this study. They were divided into two groups i-e, normouricemic group and hyperuricemic group based onserum uric acid level.Vitamin D levels of both groups were then measured. Results: The hyperuricemic group had markedly lower vitamin Dlevels as compared to normouricemic group. Moreover, vitamin D had a negative correlation with uric acid in the hyperuricemic group i-e, higher the uric acid level, lower was vitamin D. Multiple regression analysis was also performed for studying the relation of vitamin D with uric acid levels in the two groups overall. It was observed that one mg/dl increase in uric acid caused an average decrease of 2.43 ng/ml in vitamin D. Conclusion: It may be concluded from this study that association of hypovitaminosis D with hyperuricemia in postmenopausal women can be used for planning an early intervention to prevent cardiovascular diseases in them.