An association of anti-thyroid peroxidase antibodies in clinical and subclinical hypothyroidism

Abstract

Introduction: Among general people anti-thyroid antibodies and thyroid profile (TSH, T4, and T3) relation is not established. In several years presence of Anti-TPO antibodies may lead to progress of clinical thyroid disease. Therefore, to rule out underlying autoimmune method screening for Anti-TPO antibodies is required. Aim of the present study was to find an association of Anti-TPO antibodies in clinical and subclinical hypothyroidism. Materials and Methods: A cross sectional study was conducted in department of medicine and biochemistry involving 74 cases and 74 controls during the period of December 2017 to December 2018. Patien ts history, clinical examination and various investigations including FT3, FT4, TSH, Anti-TPO, FBG and lipid profile were done. Results: Out of 74 cases 30 cases had clinical hypothyroidism and 44 cases have subclinical hypothyroidism. 63.5% cases of hypothyroidism were Anti-TPO positive. 70.3% cases of Clinical hypothyroidism were Anti -TPO positive and subclinical hypothyroidism had 51.5% Anti-TPO positive. TSH had a significant positive correlation with Anti-TPO antibodies. Keywords: AntiTPO, Clinical hypothyroidism, Subclinical hypothyroidism, TSH, AntiTPO, Clinical hypothyroidism, Subclinical hypothyroidism, TSH.