Abstract
BackgroundsB3 adrenoreceptors (ADRB3) are abundant in adipose tissue and play the role in its metabolism and lipolysis. Some variants of the ADRB3 gene may predispose subjects for the development obesity and metabolic abnormalities in the setting of modern sedentary lifestyle. ADRB3 gene polymorphism association with metabolic disturbances has never been studied before in the ethnic Kyrgyz population.AimTo study an association between Trp64Arg polymorphism of the ADRB3 and metabolic syndrome (MS) components in an ethnic Kyrgyz group.Materials and methods213 Ethnic Kyrgyz volunteers over the age of 30 were enrolled in the study. The assessment plan for each individual comprised of general physical and anthropometric exams as well as laboratory tests (glucose, lipid panel, insulin) and genotyping by Trp64Arg polymorphism of the ADRB3. MS diagnosis was consistent with modified ATP III criteria (2005). Logistic regression analysis was performed to test the potential independent association between Arg64 allele with obesity, abdominal obesity (AO) and arterial hypertension (AH).ResultsTrp64Arg polymorphism of the ADRB3 was assessed in 213 individuals (145 men, 68 women) aged 30-73 (mean age 50.7 ± 7.6). Arg64 allele frequency was 0.239; ADRB3 genotype distribution among participants was: Trp64 homozygotes 54.5%, Trp64Arg 43.2% and Arg64 homozygotes 2.3%. There was an association between Trp64Arg и Arg64Arg genotypes and higher BMI, WC and obesity frequency (p < 0.00009), AO (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03). The logistic regression analysis showed the correlation of the Arg64 allele with obesity (OR 3.159; 95% CI 1.789-5.577) and AO (OR 1.973; 95% CI 1.118-3.481). The association between Arg64 allele and AH lost its significance after adjustment for obesity.ConclusionArg64 allele of the ADRB3 gene in the studied group has an association with MS components such as obesity, AO and decreased HDL-C level.
Highlights
Changes in lifestyle of the world’s population, which include increased intake of high-calorie food together with low physical activity, promote the rising prevalence of metabolic syndrome (MS), consisting of such risk factors as glucose metabolism abnormalities, dyslipidemia, Genetic predisposition plays a crucial role in the development of obesity besides traditionally acknowledged risk factors such as overeating and a sedentary lifestyle
Trp64Arg polymorphism of the B3 adrenoreceptor (ADRB3) was assessed in 213 individuals (145 men, 68 women) aged 30-73
There was an association between Trp64Arg и Arg64Arg genotypes and higher body mass index (BMI), waist circumference (WC) and obesity frequency (p < 0.00009), abdominal obesity (AO) (p < 0.01), type 2 diabetes mellitus (DM) (p < 0.005) and lower high density cholesterol (HDL-C) level (p < 0.03)
Summary
Changes in lifestyle of the world’s population, which include increased intake of high-calorie food together with low physical activity, promote the rising prevalence of metabolic syndrome (MS), consisting of such risk factors as glucose metabolism abnormalities, dyslipidemia, Genetic predisposition plays a crucial role in the development of obesity besides traditionally acknowledged risk factors such as overeating and a sedentary lifestyle. Stimulation of the ADRB3, which are abundant in visceral adipose tissue [8], activates adenylatecyclase, which in turn increases the amount of intracellular cAMP and causes enhanced lipolysis in white adipose tissue and free fatty acids delivery to the portal vein [9]. ADRB3 gene expression plays an important role in lipolysis [10]. Some studies had shown the associations between Arg variant of the ADRB3 gene and early development of type 2 DM and decreased early insulin response to glucose load [14], and, some studies with cellular transfection had shown an association with decreased glucose dependent insulin secretion [15]
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