Abstract
BackgroundThe main purpose of the present study is to evaluate whether treatment with long-acting human glucagon-like peptide-1 liraglutide was associated with an improvement of excessive daytime sleepiness (EDS) in obese subjects with type-2 diabetes.MethodsThis single-centre retrospective study included 158 obese (body mass index [BMI] ≥ 30 kg/m2) adult subjects with type-2 diabetes who were initiated with liraglutide treatment at least 3 months before study inclusion. Data of the Epworth Sleepiness Scale (ESS), anthropometric parameters, glucose-control and metabolic parameters were collected at liraglutide initiation (baseline) and at months 1 and 3 after liraglutide initiation.ResultsSignificant reductions in ESS score were achieved at months 1 (−1.3 ± 2.8, p < 0.001) and 3 (−1.5 ± 3.0, p < 0.001) after liraglutide introduction. After 3 months of treatment with liraglutide, significant changes in body weight (p < 0.001), BMI (p < 0.001), waist (p < 0.001) and neck circumferences (p < 0.005), HbA1c (p < 0.001), mean blood glucose (p < 0.001), fasting plasma glucose (p < 0.001), triglycerides (p < 0.01) and total cholesterol (p < 0.001) were achieved.ConclusionsAfter 3 months of treatment with liraglutide a significant reduction in EDS was observed in obese subjects with type-2 diabetes. Besides this, significant changes in body weight and metabolic parameters of diabetes control were also accomplished. Further investigation is required to determine whether liraglutide could improve other abnormal sleep patterns and obstructive sleep apnoea.
Highlights
The main purpose of the present study is to evaluate whether treatment with long-acting human glucagon-like peptide-1 liraglutide was associated with an improvement of excessive daytime sleepiness (EDS) in obese subjects with type-2 diabetes
Subjects characteristics Between March 2012 and June 2013, a total of 163 subjects were included
To the best of our knowledge, this is the first study showing an association of liraglutide-induced body weight reduction and an improvement of EDS in obese subjects with type 2 diabetes in routine clinical practice
Summary
The main purpose of the present study is to evaluate whether treatment with long-acting human glucagon-like peptide-1 liraglutide was associated with an improvement of excessive daytime sleepiness (EDS) in obese subjects with type-2 diabetes. Methods: This single-centre retrospective study included 158 obese (body mass index [BMI] ≥ 30 kg/m2) adult subjects with type-2 diabetes who were initiated with liraglutide treatment at least 3 months before study inclusion. Abnormal sleep patterns (ASPs), characterized by short or long durations of sleep and excessive daytime sleepiness (EDS), have a considerable impact on an individual’s health [1]. Liraglutide, a long-acting human glucagon-like peptide receptor agonist (GLP-1ra) [17], is indicated for the treatment of type 2 diabetes. Liraglutide exerts its potent glucose-lowering effect through different mechanisms that lead to clinically significant reductions in glycated haemoglobin (HbA1c) and body weight [18]. A reduction of insulin resistance has been proved in patients with type 2 diabetes treated with liraglutide [19]
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