Abstract

BackgroundRecent studies have shown that triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) are related to the prevalence of cardiovascular autonomic neuropathy (CAN). However, little is known about the association of lipid profile with diabetic cardiovascular autonomic neuropathy (DCAN), or its severity in the Chinese population. The purpose of this study is to explore the extent of this phenomenon using a Chinese sample.MethodsA subgroup analysis on 455 diabetic patients with undiagnosed DCAN was performed to evaluate the relationships of lipids profile and DCAN. DCAN was diagnosed if there were at least two abnormal cardiovascular autonomic reflex test results, based on short-term heart rate variability tests. Multivariable logistic regression (MLR)was carried out to control potential confounders for determining the independent association of variables with DCAN in different models.ResultsMLR analysis indicated that TG was significantly and independently associated with DCAN when controlling for confounding factors (P < 0.1 for two models). Additionally, TG combined with TC (LRS-1) and LDL (LRS-2) was associated with this outcome (P < 0.1 for LRS-1 and LRS-2).ConclusionOur findings indicate that TG and the severity of lipids profile is significantly and independently associated with DCAN, respectively.Trial registrationClinicalTrials.gov Identifier: NCT02461472, retrospectively registered 2 Jun, 2015

Highlights

  • Recent studies have shown that triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) are related to the prevalence of cardiovascular autonomic neuropathy (CAN)

  • We focused on exploring the extent to which association of lipid profiles and its severity with diabetic cardiovascular autonomic neuropathy (DCAN) in a Chinese sample

  • To the best of our knowledge, this is the first use of LPS to model lipids profile and its severity, in order to explore the extent to which lipids profile is associated with DCAN in the Chinese population

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Summary

Introduction

Recent studies have shown that triglyceride (TG), low-density lipoprotein cholesterol (LDL), and high-density lipoprotein cholesterol (HDL) are related to the prevalence of cardiovascular autonomic neuropathy (CAN). Recent data has shown that only 55.9 % of outpatients in the top-ranked hospitals in the major cities of China were treated for dyslipidemia, with only 39.4 % of them achieving the LDL goal [4]. Data published recently indicates that CM risk factors are highly prevalent among youths and young adults, which poses a high risk of death from diabetes and cardiovascular disease in China [6]. The Chinese healthcare system is heavily burdened by CM diseases, which are the leading causes of morbidity and mortality in China [7, 8].

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