Abstract
The mitochondrial (mt) DNA C5178A and A10398G polymorphisms have been reported to be associated with mental disorders such as bipolar disorder. However, the effects of these polymorphisms on temperament in healthy people are poorly understood. Evaluating healthy subjects can have the advantage of providing new strategies for maintaining psychological health and preventing mental illness. We examined the association between mtDNA polymorphisms and temperament in Japanese students. There was no significant difference in examined temperament when analysed by genotypes, 5178–10398 haplotypes, or sex. The subgroup analysis based on sex indicated that there was an interactive effect of the mtDNA A10398G polymorphism and sex on anxiety and obsession. This finding is preliminary and cannot exclude the possibility of false-positive due to small sample size (144 subjects) and multiple statistical testing. Further studies involving a larger sample size or other ethnic groups are necessary to confirm that mtDNA A10398G polymorphism can be a genetic factor for temperament.
Highlights
Mitochondria are major organelles which generate adenosine triphosphate (ATP) for energy production
Evaluating healthy subjects can have the advantage of providing new strategies for maintaining psychological health and preventing mental disorders
No significant difference in all University Personality Inventory (UPI) scores was observed when analysed by genotypes, 5178– 10398 haplotypes, or sex (Table 1)
Summary
Mitochondria are major organelles which generate adenosine triphosphate (ATP) for energy production. The mtDNA C5178A polymorphism, the missense Leu237Met variation, is common in almost only Asian and has been reported to be associated with bipolar disorder [7]. One report suggests the mtDNA C5178A polymorphism may be involved in personality trait [8].
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