Abstract
Purpose. To compare the stages of vitreous degeneration in patients with vitreomacular traction (VMT) and macular holes (MH). Methods. A retrospective study was performed analyzing stages of vitreous degeneration of eyes with VMT or MH using swept-source optical coherence tomography (SS-OCT) and spectral-domain optical coherence tomography (SD-OCT). An analogous review was performed on a control group of eyes with contralateral posterior vitreous detachments. Thirty-four eyes with VMT/MH and 39 control eyes were reviewed. Results. Twenty-seven VMT/MH eyes and 31 control eyes were included. Eyes with VMT/MH demonstrated significantly earlier stages of vitreous degeneration when compared to the control group (p = 0.048) despite significantly greater age (p = 0.032). Conclusions. Vitreoretinal interface disease is more often associated with a formed vitreous and an intact premacular bursa. This is contrary to previous assumptions implicating degeneration of vitreous as a precipitating factor of interface disease when in conjunction with abnormal vitreomacular separation.
Highlights
Multimodal imaging has promoted a better understanding of vitreoretinal interface disease
A total of 34 eyes in the vitreomacular traction (VMT)/macular holes (MH) group and 39 eyes in the control group were reviewed for the study
After excluding eyes with disagreement between evaluators, 27 eyes were included in the VMT/MH group and 31 eyes in the control group
Summary
Multimodal imaging has promoted a better understanding of vitreoretinal interface disease. Our understanding of the role of the vitreous body itself in this spectrum of disease has been neglected. It is typically accepted that progression of vitreous degeneration may be responsible for disease in an eye with a pathologically adherent cortical vitreous [1]. This theory has not been substantiated by in vivo imaging modalities. The idea that vitreous degeneration may not, be positively correlated with vitreoretinal interface disease originated from the authors’ anecdotal observations during
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