Abstract
Hard Keratin (HK) from goat horn discards was dissolved using Ionic Liquid (IL) called Tetrabutylammonium hydroxide (TBAH, 40% aqueous solution), particles of HK were extracted, evaluated for antioxidant potential and in vitro cell viability against A549 and HEK-293 cell lines. Different material characterization techniques viz. PFM, XRD, FESEM/EDAS, FTIR, and TGA were employed to characterize the extracted hard keratin. PFM characterization revealed a piezoelectric coefficient (d33) of about 22.6 pm/V. FTIR analysis confirmed the presence of reactive Amides I, II & III at 1681, 1527, and 1249 cm-1 respectively. XRD spectrum demonstrated the amorphous phase of the material, and the Crystalline Index (C.I.) is 0.38. Characterization by TGA represents high thermal stability of extracted HK with a mass loss of 64.6% at 974.5°C temperature, reflective of the desired thermal stability for different applications. HK particles showed considerable antioxidant activity and inhibition of Human cell lines to an extent of 40.4% at 10 μg concentration for A549 (Lung Carcinoma cells) and 8.38% at 100 μg for HEK-293 (Human embryonic kidney cells).
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