Abstract
We assessed the effectiveness of the registry of Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, with a total of 35,117 hematopoietic stem cell donors recruited in 22 regions of the Russian Federation (as of 01 January 2019). It was established that a relatively small registry would be sufficient to find at least one fully matched donor for 43% of Russian patients. The sufficient representativeness of this hematopoietic stem cell donor registry is confirmed by the high concordance of established HLA haplotype profiles between the population of donors and the cohort of patients for whom a search of a matching donor was performed. This study was approved by the Independent Ethics Committee and Scientific Council of Kirov Research Institute of Hematology and Blood Transfusion, FMBA of Russia.
Highlights
We assessed the effectiveness of the registry of Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, with a total of 35,117 hematopoietic stem cell donors recruited in 22 regions of the Russian Federation
The sufficient representativeness of this hematopoietic stem cell donor registry is confirmed by the high concordance of established HLA haplotype profiles between the population of donors and the cohort of patients for whom a search of a matching donor was performed
Число доноров гемопоэтических стволовых клеток (ГСК), рекрутированных в регионе, n Number of HSC donors recruited in the region, n
Summary
ФГБУН «Кировский научно-исследовательский институт гематологии и переливания крови Федерального медико-биологического агентства», Киров. Проведена оценка эффективности регистра ФГБУН КНИИГиПК ФМБА России, включавшего по состоянию на 01.01.2019 35 117 доноров гемопоэтических стволовых клеток, рекрутированных в 22 регионах Российской Федерации. An assessment of the effectiveness of the search for unrelated hematopoietic stem cell donors for russian patients in the registry of Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia. We assessed the effectiveness of the registry of Kirov Research Institute of Hematology and Blood Transfusion, Federal Medical and Biological Agency of Russia, with a total of 35,117 hematopoietic stem cell donors recruited in 22 regions of the Russian Federation (as of 01 January 2019). В связи с этим представляется актуальным провести оценку эффективности и репрезентативности регистра ФГБУН КНИИГиПК ФМБА России для российской когорты пациентов, нуждающихся в аллогенной трансплантации ГСК
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