Abstract
Background and Objectives: Altered glycosylation of glycoconjugates is among the important molecular changes that accompany malignant transformation. Various studies in the past have shown the direct relation of Total Sialic acid in premalignant lesions and different malignancies. The purpose of this study is to investigate clinical usefulness of circulatory levels of Total Sialic acid in Leukoplakia, Squamous cell carcinoma and healthy controls of age and sex matched subjects. Method: Blood samples were collected from 25 untreated Leukoplakia, 25untreated Squamous cell carcinoma and 25 healthy subjects. Total serum Sialic acid were evaluated by the simplified quick method by G Sydow and measured spectrophotometrically at 525nm. Results: Serum levels of Total Sialic acid were significantly elevated (P
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